!Citation=Paulus C, et al. (2006) J Virol 80(4):1773-86 !Title=Transcriptome signature of virulent and attenuated pseudorabies virus-infected rodent brain. !PubMedID=16439534 !Name=Brain transcriptional response to pseudorabies virus infection !ExptSetNo=5060 !Description=A systematic analysis of the host gene expression profile after acute pseudorabies virus (PRV) infection of the central nervous system. Rats were mock-infected or injected intraocularly with one of three selected virulent or attenuated PRV strains (PRV151, PRV152, or PRV99G). Relative levels of cellular transcripts were quantified from hypothalamic and cerebellar tissues at various times post-infection (48, 60, and 96 hours). The number of cellular genes responding to infection correlated with the extent of viral dissemination and relative virulence of the PRV strains. A total of 245 out of 8,799 probe sets, corresponding to 182 unique cellular genes, displayed increased expression ranging from two- to more than 100-fold compared to uninfected tissue. Over 60% thereof were categorized as immune, pro-inflammatory and other cellular defense genes. Additionally, a large fraction of infection-induced transcripts represented cellular stress responses, including glucocorticoid- and redox-related pathways.