!Name=Gene Expression Profiles of cutaneous B-cell lymphoma !ExptSetNo=1798 !Description=We studied gene expression profiles of 17 cutaneous B-cell lymphomas that were collected with 4-6 millimeter skin punch biopsies. We also included tissue from 2 cases of mycosis fungoides (MF), 3 normal skin biopsies and 3 tonsils to create a framework for further interpretation. A hierarchical cluster algorithm was applied for data analysis. Our results indicate that small amounts of skin tissue can be used successfully to perform microarray analysis and result in distinct gene expression patterns. Duplicate specimens clustered together demonstrating a reproducible technique. Within the cutaneous B-cell lymphoma specimens two specific B-cell differentiation stage signatures of germinal center B-cells and plasma cells could be identified. Primary cutaneous follicular and primary cutaneous diffuse large B-cell lymphomas had a germinal center B-cell signature while a subset of marginal zone lymphomas demonstrated a plasma cell signature. Primary and secondary follicular B-cell lymphoma of the skin were closely related, despite previously reported genetic and phenotypic differences. In contrast primary and secondary cutaneous diffuse large B-cell lymphoma were less related to each other. This pilot study allows a first glance into the complex and unique microenvironment of B-cell lymphomas of the skin and provides a basis for future studies, that may lead to the identification of potential histologic and prognostic markers as well as therapeutic targets. !Name=CBCL DLCL 98-007 !Exptid=22129 !Name=CBCL FL 98-023b !Exptid=23546 !Name=CBCL DLCL 98-010b !Exptid=23556 !Name=CBCL DLCL/MZL 98-020 !Exptid=22143 !Name=CBCL FL 97-022b !Exptid=23553 !Name=CBCL FL 97-022D !Exptid=26140 !Name=CTCL MF 01-002b !Exptid=23569 !Name=CTCL MF 01-003b !Exptid=24105 !Name=Normal Skin 01-04 !Exptid=26144 !Name=Normal Skin 02-01 !Exptid=26142 !Name=Normal Skin 02-02 !Exptid=26143 !Name=PCBCL DLCL 01-012b !Exptid=24108 !Name=PCBCL DLCL 89-004b !Exptid=23550 !Name=PCBCL DLCL 89-004D !Exptid=26141 !Name=PCBCL FL 94-001 !Exptid=22004 !Name=PCBCL FL 95-025b !Exptid=23563 !Name=PCBCL FL 96-002 !Exptid=22049 !Name=PCBCL FL 97-009 !Exptid=22141 !Name=PCBCL FL96-003 !Exptid=22005 !Name=PCBCL MZL 97-016 !Exptid=22025 !Name=PCBCL MZL 01-018 !Exptid=22128 !Name=PCBCL MZL 91-015 !Exptid=22008 !Name=PCBCL MZL 92-013b !Exptid=24110 !Name=PCBCL MZL 96-005 !Exptid=22050 !Name=Tonsil 84-01 !Exptid=26145 !Name=Tonsil 86-03 !Exptid=26147 !Name=Tonsil 93-02 !Exptid=26146