!Name=Higgins et al (2003) : Renal Cell Carcinoma !ExptSetNo=1890 !Description=Materials and Methods Results Discussion References Renal cell carcinoma comprises several histological types with different clinical behavior. Accurate pathological characterization is important in the clinical management of these tumors. We describe gene expression profiles in 41 renal tumors determined by using DNA microarrays containing 22,648 unique cDNAs representing 17,083 different UniGene Clusters, including 7230 characterized human genes. Differences in the patterns of gene expression among the different tumor types were readily apparent; hierarchical cluster analysis of the tumor samples segregated histologically distinct tumor types solely based on their gene expression patterns. Conventional renal cell carcinomas with clear cells showed a highly distinctive pattern of gene expression. Papillary carcinomas formed a tightly clustered group, as did tumors arising from the distal nephron and the normal kidney samples. Surprisingly, conventional renal cell carcinomas with granular cytoplasm were heterogeneous, and did not resemble any of the conventional carcinomas with clear cytoplasm in their pattern of gene expression. Characterization of renal cell carcinomas based on gene expression patterns provides a revised classification of these tumors and has the potential to supply significant biological and clinical insights. !Name=CKR001 Conventional/clear RCC II Caval Thrombus !Exptid=2372 !Name=CKT001 Conventional/clear RCC II !Exptid=3665 !Name=CKT002 Conventional/clear RCC III !Exptid=4434 !Name=CKT003 Conventional/clear RCC III !Exptid=1935 !Name=CKT006 Conventional/clear RCC I !Exptid=5057 !Name=CKT030-Oncocytoma !Exptid=13602 !Name=Perth 00-0130 Conventional/clear cell RCC II !Exptid=6270 !Name=Perth 99-1182 Conventional/clear cell RCCA II !Exptid=6271 !Name=Perth 99-1262 Conventional/clear cell RCC II !Exptid=4941 !Name=PKT001 Conventional/granular RCC III !Exptid=6267 !Name=PKT002 Conventional/clear cell RCCA I !Exptid=2329 !Name=PKT003 Conventional/clear RCCA II !Exptid=3448 !Name=PKT004 Conventional/granular RCCA II !Exptid=4954 !Name=PKT005 Chromophobe RCCA III !Exptid=4957 !Name=SKN003 Normal Kidney !Exptid=4527 !Name=SKN005 Normal Kidney !Exptid=2373 !Name=SKN013 Kidney !Exptid=3668 !Name=SKR012 Conventional/clear RCCA III Thrombus !Exptid=3443 !Name=SKR032-Conventional/clear RCC thrombus !Exptid=13663 !Name=SKT002 Conventional/clear RCCA II !Exptid=4522 !Name=SKT003 Conventional/clear RCCA III !Exptid=2328 !Name=SKT004 Conventional/clear RCCA II !Exptid=2300 !Name=SKT006 Conventional/clear RCCA II !Exptid=3667 !Name=SKT008 Conventional/granular RCCA III !Exptid=3680 !Name=SKT009 AML !Exptid=5900 !Name=SKT010 Chromophobe RCCA II !Exptid=1934 !Name=SKT011 Conventional/clear RCCA II !Exptid=3669 !Name=SKT012 Conventional/clear RCCA III !Exptid=3438 !Name=SKT014 Oncocytoma !Exptid=6272 !Name=SKT016 Papillary RCCA III !Exptid=5068 !Name=SKT017 Conventional/clear RCCA II !Exptid=5108 !Name=SKT018 Conventional/granular RCCA III !Exptid=5109 !Name=SKT019 Chromophobe RCCA IV !Exptid=5081 !Name=SKT022 Papillary RCCA II !Exptid=5110 !Name=SKT023 Conventional/clear RCCA II !Exptid=5903 !Name=SKT024 Conventional/clear RCCA II !Exptid=5907 !Name=SKT026 Conventional/clear RCCA III !Exptid=6268 !Name=SKT027 Conventional/clear RCCA III !Exptid=6269 !Name=SKT029-Conventional/granular RCC II !Exptid=13653 !Name=SKT030-Papillary RCC II !Exptid=13656 !Name=SKT032-Conventional/clear RCC III !Exptid=13659 !Name=SKT033-Papillary RCC II !Exptid=13665 !Name=SKT034-conventional/clear RCC II !Exptid=14509 !Name=SKT035B-conventional/clear RCC II !Exptid=14510