!Citation=Lin JY, et al. (2002) Genome Biol 3(6):RESEARCH0026 !Title=Physical mapping of genes in somatic cell radiation hybrids by comparative genomic hybridization to cDNA microarrays. !PubMedID=12093373 !Name=array-CGH !ExptSetNo=1524 !Description=Somatic cell mutants can be informative in the analysis of a wide variety of cellular processes. The use of map- based positional cloning strategies in somatic cell hybrids to analyze genes responsible for recessive mutant phenotypes is often tedious, however, and remains a major obstacle in somatic cell genetics. To fulfill the need for more efficient gene mapping in somatic cell mutants, we have developed a new DNA microarray comparative genomic hybridization (array-CGH) method that can rapidly and efficiently map the physical location of genes complementing somatic cell mutants to a small candidate genomic region. Here we report experiments that establish the validity and efficacy of the methodology.