!Name=LymphomaTransformation !ExptSetNo=963 !Description=Transformation of Follicular Lymphoma to Diffuse Large Cell Lymphoma: Alternative Patterns with Increased or Decreased Expression of c-myc and its Regulated genes The natural history of follicular lymphoma (FL) is frequently characterized by transformation to a more aggressive diffuse large B cell lymphoma (DLBCL). We compared the gene expression profiles between transformed DLBCL and their antecedent FL. No genes were observed to increase or decrease their expression in all the cases of histological transformation. However, two different gene expression profiles associated with the transformation process were defined, one in which c-myc and genes regulated by c-myc showed increased expression and one in which these same genes showed decreased expression. Further, there was a striking difference in gene expression profiles between transformed DLBCL and de novo DLBCL, since the gene expression profile of transformed DLBCL was more similar to their antecedent FL than to de novo DLBCL. The study demonstrates that transformation from FL to DLBCL can occur by alternative pathways and that transformed DLBCL and de novo DLBCL have very different gene expression profiles that may underlie the different clinical behaviors of these two types of morphologically similar lymphomas. !Name=IL105 Type1: FL to DLBCL Transformation !Exptid=15238 !Name=IL116 Type1: FL to DLBCL Transformation !Exptid=15242 !Name=IL124 Type1: FL to DLBCL Transformation !Exptid=15247 !Name=IL114 Type1: FL to DLBCL Transformation !Exptid=15254 !Name=IL124 Type1: FL to DLBCL Transformation; #2 !Exptid=15261 !Name=IL117 Type1: FL to DLBCL Transformation !Exptid=15272 !Name=IL119 Type1: FL to DLBCL Transformation !Exptid=15276 !Name=IL120 Type1: FL to DLBCL Transformation !Exptid=15288 !Name=IL121 Type1: FL to DLBCL Transformation !Exptid=15298 !Name=IL122 Type1: FL to DLBCL Transformation !Exptid=15301 !Name=IL123 Type1: FL to DLBCL Transformation !Exptid=15305 !Name=IL125 Type1: FL to DLBCL Transformation !Exptid=15309 !Name=IL126 Type1: FL to DLBCL Transformation !Exptid=15314 !Name=IL119A Type 2a !Exptid=15875 !Name=IL117B Type 2a !Exptid=15872 !Name=IL117A Type 2a !Exptid=15868 !Name=IL116B Type 2a !Exptid=15865 !Name=IL116A Type 2a !Exptid=15862 !Name=IL114C Type 2a !Exptid=15857 !Name=IL114B Type 2a !Exptid=15854 !Name=IL114A Type 2a !Exptid=15851 !Name=IL105B Type 2a !Exptid=15828 !Name=IL105A Type 2a !Exptid=15827 !Name=GC 43 Type 2a !Exptid=15906 !Name=IL126B Type 2a !Exptid=15905 !Name=IL122A Type 2a !Exptid=15891 !Name=IL122B Type 2a !Exptid=15894 !Name=IL123A Type 2a !Exptid=15896 !Name=IL123B Type 2a !Exptid=15898 !Name=IL123C Type 2a !Exptid=15899 !Name=IL124A Type 2a !Exptid=15900 !Name=IL124B Type 2a !Exptid=15901 !Name=IL125A Type 2a !Exptid=15902 !Name=IL125B Type 2a !Exptid=15903 !Name=IL126A Type 2a !Exptid=15904 !Name=IL121B Type 2a !Exptid=15888 !Name=IL121A Type 2a !Exptid=15884 !Name=IL120B Type 2a !Exptid=15882 !Name=IL120A Type 2a !Exptid=15880 !Name=IL119B Type 2a !Exptid=15877 !Name="DLCL-0037, GCB-Like Type2a" !Exptid=16931 !Name="DLCL-0023, GCB-Like Type2a" !Exptid=16933 !Name="DLCL-0024, GCB-Like Type2a" !Exptid=16940 !Name="DLCL-0029, GCB-Like Type2a" !Exptid=16942 !Name="DLCL-0051, GCB-Like Type2a" !Exptid=16943 !Name="DLCL-0052, GCB-Like Type2a" !Exptid=16945 !Name="DLCL-0048, ABC-Like Type2a" !Exptid=16947 !Name="DLCL-0047, ABC-Like Type2a" !Exptid=16949 !Name="DLCL-0027, ABC-Like Type2a" !Exptid=16951 !Name="DLCL-0039, ABC-Like Type2a" !Exptid=16953 !Name="DLCL-0049, ABC-Like Type2a" !Exptid=16954 !Name=SUDHL6 Type2 !Exptid=15799 !Name=OCI-Ly3 Type2 !Exptid=15797 !Name=OCI-Ly10 Type2 !Exptid=15798